CD4 and rheumatoid arthritis: The interesting observation in this study was diminished TCR-mediated induction of IL-1RII, and not IL-1RI, on memory CD4+ T cells from RA patients compared to the peripheral counterpart from healthy controls (Figure 7D), causing a significantly reduced ratio of IL-1RI+IL-1RII+ to IL-1RI+IL-1RII- memory CD4+ T cells (Figure 7E).