SMAD3 and cancer: Consequently, EGFR was lowly expressed in the cancer group versus the normal group in LUAD without a statistical difference (P-value: 0.19) (Figure 8A) and this expression pattern was similar to ESR1 (P-value: 0.42), MYC (P-value: 0.067), RELA (P-value: 0.058) and SMAD3 (P-value: 0.13) (Figure 8B,C,E,F).