In addition, isorhamnetin increases protein levels of light chain 3-II when autophagy is initiated, up-regulates the expression of Beclin1, an activator of PI3K, and promotes accumulation of monodansylcadaverine, an in vivo marker for autophagic vacuoles, which confirm the effects of isorhamnetin on autophagy induction in NSCLC cells [52]. This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.