LIPA and Wolman disease: As mentioned above, cholestane‐3β,5α,6β‐triol is elevated in the circulation people with Niemann–Pick type C and type B disease and also those with lysosomal acid lipase (LIPA, EC:3.1.1.13) deficiency, known as Wolman disease when there is a complete absence of the enzyme [48, 68, 126].