RB1 and head and neck squamous cell carcinoma: Furthermore, inactivation of SMARCA4, the catalytic subunit of the SWI/SNF chromatin remodelling complex, has been linked to impaired nucleotide excision repair (NER) [23] and loss of Rb activity [24], and thereby increased platinum sensitivity in HNSCC and NSCLC cell lines [23] and NSCLC patients [25], which contrasts our findings of resistance to platinum‐containing CRT.