Our findings of a higher natriuresis in hyponatremic patients on D7 could be the consequence of this latter effect and are potentially relevant clinically as, along with the experimental evidence, they may suggest a contributing role of SIOXT in the SIADH-associated hyponatremia, with an increased renal excretion of sodium related to an increased OXT secretion, thus aggravating the phenomenon by counteracting the previously reported antinatriuretic effects of AVP on the kidney [32, 33]. Here, OXT is linked to inappropriate ADH syndrome.