PTEN and neoplasm: Furthermore, increasing research evidence shows that TRIM family proteins are essential regulators of tumorigenesis and development and play crucial functions in the biological signs of progress comprising tumor cell differentiation, proliferation, apoptosis, invasion, and migration, among which TRIM19, TRIM24, TRIM33, and TRIM2 mainly obtain the oncogene characteristics through chromosomal rearrangement [6], TRIM27 downregulates its tumor-suppressive effect by mediating the atypical ubiquitination of the tumor suppressor gene PTEN [20].