It is known that not only tumor cells participate in favoring EMT, but also tumor-infiltrating immune cells, through the secretion of different soluble factors (transforming growth factor- (TGF-) β, IL-6, TNF-α, CCL18, IFN-γ, VEGF, among others), have a positive feedback in the promotion of this process in cancer [111]. The gene discussed is TNF; the disease is neoplasm.