The nine core genes of the model, IGSF5 [13], NKX2-3 [14], HLF [15], ALDH2 [16], IFIT2 [17], FXYD5 [18], CTSL1 [19], IFNAR1 [20], and RNF216 [21], have been associated with tumor occurrence and development. This evidence concerns the gene RNF216 and neoplasm.