Similar to NKT cells, these CD1-restricted cell populations are considered an attractive target for studies in the field of cancer immunotherapy, especially in the context of hematological neoplasms, due to the diversified distribution of CD1 isotypes, where they have been shown to be expressed (CD1a, CD1b, and CD1c) in 75% of acute leukemia blasts [153]. This evidence concerns the gene CD1B and hematopoietic and lymphoid system neoplasm.