Moreover, a study indicated that SARS-CoV-2 could directly bind to ACE2 receptor of cells with high affinity [11], and the expression of ACE2 may be increased in DM patients treated with ACEI, ARB, and thiazolidinediones, which may be associated with increased risk of developing severe and fatal COVID-19 [12]. The gene discussed is ACE2; the disease is COVID-19.