APOE and Alzheimer disease: It has been found that a low dose of benzodiazepine clonazepam (0.05 mg/kg) is beneficial to AD [42], and a daily peritoneal injection of the GABA-A receptor potentiator pentobarbital sodium rescues the learning and memory impairment in ApoE4-Ki mice, while the GABA-A receptor antagonist reverses this rescue [30].