Our data (Figure 2) showed that the epithelioid-derived PANC-1 expressed more SPHK1 and HAS2, compared to these metastatic site-derived Capan-1 and AsPC1, suggesting that SPHK1 and HAS2 may be related to the origin of pancreatic cancer cell lines. The gene discussed is SPHK1; the disease is familial pancreatic carcinoma.