GHRL and type 2 diabetes mellitus: Karege et al. have reported that BDNF is closely related with T2DM and has a major impact on the pathogenesis of weight and T2DM via alteration of the secretion and action of insulin, leptin, ghrelin, neurotransmitters/neuropeptides, and proinflammatory cytokines related with vitality homeostasis [38].