In chronic obstructive pulmonary disease patients, the PVT1 expression positively correlated with the GOLD stage and levels of TNF-α, IL-6, IL-8, and IL-17 [25]; PVT1 exacerbates the inflammation and cell-barrier injury during asthma by regulating miR-149 [26]. The gene discussed is CXCL8; the disease is asthma.