In addition to the formation of dendritic spines in neurons and mobility enhancement of cancer cells, Kaur et al. reported that IRSp53 interacted with cell division cycle 42 (Cdc42), a guanosine triphosphate binding protein, to induce the formation of filopodia and migration of endothelial cells [14] which is essential for homeostasis of the cardiovascular system [15]. Here, CDC42 is linked to cancer.