Three previously published HCC-related signatures derived from TCGA successfully and significantly predict the OS outcomes, including five-ARG signature (HDAC1, RHEB, ATIC, SPNS1, and SQSTM1) by Huo et al. (2020) four-lncRNA signature (ENSG00000234608, ENSG00000242086, ENSG00000273032, ENSG00000228463) by Yang et al. (2020) and four-lncRNA signature (RP11-322E11.5, RP11-150O12.3, AC093609.1, CTC-297N7.9) by Wang et al. (2017). This evidence concerns the gene RHEB and hepatocellular carcinoma.