Given that most VRL cases are of the ABC DLBCL subtype (Araujo and Coupland, 2017; Karakawa et al., 2018; Chen et al., 2019; Fan et al., 2019) and that BCL2 is more commonly found in GCB DLBCL (Barrans et al., 2002; Iqbal et al., 2004; Chen et al., 2010), the high occurrence of the BCL2 translocation in patients with VRL as reported by Wallace et al. (2006) is intriguing (Fend et al., 2016; Kalogeropoulos et al., 2019). This evidence concerns the gene BCL2 and aneurysmal bone cyst.