Of the known human coloboma-associated genes (as listed in Patel and Sowden, 2017; ALSomiry et al., 2019) only PAX2, ALDH1A3 (ALDH6), STRA6 and SMOC1 were found to among the genes that were significantly enriched in both chick and zebrafish datasets at the OF during fusion (Hardy et al., 2019; Richardson et al., 2019). This evidence concerns the gene ALDH1A3 and coloboma.