At the cellular level, FTO promoted the proliferation and mammosphere formation and suppressed cell apoptosis by inhibiting BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3; i.e., a pro-apoptosis protein of the Bcl-2 family) in BC (Niu et al., 2019) (Figure 2). Here, BCL2 is linked to breast cancer.