In a mouse model of the orthotopic transplantation of BC tumors, ALKBH5-deficient MDA-MB-231 cells developed fewer tumors compared with the control group (43% vs. 100%), and only a few small lung metastases were found in the ALKBH5 knockdown group, thus confirming that ALKBH5 promoted the initiation of BC and lung metastasis (Zhang et al., 2016b). The gene discussed is ALKBH5; the disease is breast cancer.