Inhibition of ABCD3 by means of a specific antibody substantially decreased beta-oxidation of C26:0 in isolated peroxisomes but not in homogenates from X-ALD fibroblasts, which suggests that ABCD3 accounts for the residual beta-oxidation activity (about 30%) measured in these fibroblasts (Wiesinger et al., 2013). Here, ABCD3 is linked to X-linked adrenoleukodystrophy.