TLR4 and familial pancreatic carcinoma: Subsequently, the stimulation of TLRs can actuate some adverse protumoral signaling pathways, such as TLR2, TLR4, and TLR9, which activate signaling pathways and anti-apoptotic Bcl-xL expression in terms of tumor cell activation and proliferation in pancreatic cancer (Grimmig et al., 2016).