For instance, dual inhibition of PI3K-γ and CSF-1R by a nanomicelle encapsulating the PI3K-γ inhibitor BEZ 235 and CSF-1R-siRNA has been reported to largely diminish M2 macrophage infiltration and remove the immune blockade in the tumor microenvironment of PDAC (Li et al., 2020). The gene discussed is CSF1R; the disease is neoplasm.