Furthermore, TAM-derived IL-6 induces the phosphorylation of PDPK1-mediated PGK1 threonine (T) 243 in tumor cells, to facilitate a PGK1-catalyzed reaction toward glycolysis by altering substrate affinity, which upholds PDAC initiation in a metabolic regulation way. The gene discussed is PDPK1; the disease is neoplasm.