Since there is evidence that suggests defective autophagy and oxidative stress contribute to AMD pathophysiology (Jarrett and Boulton, 2012; Mitter et al., 2012; Golestaneh et al., 2017), it would be interesting to investigate the association of POLDIP2 to oxidative damage and autophagy and determine how it contributes to AMD pathogenesis. Here, POLDIP2 is linked to age-related macular degeneration.