It should be noted that further study is necessary to explore the potential functions of nuclear MALAT1. Despite the limitations in the current study and the challenges in this field, this study provided novel insight into the role of the MALAT1/miR-320a-5p/Runx2 signaling pathway in the potential molecular mechanism of RP formation, and further studies are anticipated to explore the roles of lncRNAs in the context of RP formation. The gene discussed is RUNX2; the disease is retinitis pigmentosa 1.