The polymorphism in the patatin-like phospholipase domain-containing 3 (PNPLA3) and the transmembrane 6 superfamily member 2 (TM6SF2) genes are associated with NAFLD, NASH, fibrosis, and an increased risk of hepatocellular carcinoma [38]. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.