These include KMT2D, HIST1H1E, CHD8, and BCL7A, with some additional genes identified that involve epigenetic regulatory pathways including DNMT1. Both LMP1 and LMP2A have been found to increase expression of DNA methyltransferases including DMNT1 in carcinomas, leading to inhibition of E-cadherin (CDH1) and PTEN expression (Tsai et al., 2006; Hino et al., 2009). This evidence concerns the gene CDH1 and carcinoma.