p53 mutants R175H, R273H, and D281G were shown to coopt the NF-κB transcription factor to produce a plethora of secreted inflammatory chemokines including CXCL5, CXCL8, and CXCL12 (12) that stimulate cell proliferation and motility, thus driving tumor aggressiveness. The gene discussed is TP53; the disease is neoplasm.