TP53 and familial pancreatic carcinoma: In pancreatic cancers, mutant p53 activates the NF-Y transcription complex by releasing p73, resulting in transactivation of PDFGR-β (Figure 3A), promoting cell migration, while in glioblastoma PTEN promotes the association of mutant p53 with NF-Y to induce expression of Myc and Bcl-XL (110, 122).