To control for any possible confounding factors affecting the association between serum prealbumin and the risk of all-cause mortality, subsequent multivariate Cox regression and RCS models were adjusted for age, sex, tumor size and number, tumor capsule, AFP, HBsAg, ALB, AST, ALT, TBIL, Child-Pugh, liver cirrhosis, and BCLC stage. This evidence concerns the gene TTR and cirrhosis of liver.