VSIR and esophageal adenocarcinoma: In this study, TNBC patients with VISTA-positive ICs, especially the T1-2N0 stage patients and basal-like subgroup patients had a significantly favorable prognosis in terms of RFS and OS Recent studies on esophageal adenocarcinoma (28) and breast cancer (29) also confirmed that high levels of VISTA in ICs was related to a better prognosis.