STING1 and neoplasm: Among the 10 significant cancer pairs (shown in red in Table S2) found with SimSIP, not WeiSumE*, five cancer pairs can be explained in pan-cancer studies: For cancer pair COAD and UCEC, the diversity of high antigen-specific TCR repertoires correlates with the improved prognostic progression-free interval in COAD and UCEC (Thorsson et al., 2018); the expression of TMEM173 in tumor tissues is significantly upregulated and hypomethylated in cancer pair COAD and THCA but significantly downregulated and hypermethylated in cancer pair LUSC and PRAD (An et al., 2019).