These results suggested that the miR-875-5p directly targeted CAPZA1 3′UTR(T), and consistently, the SNP rs373245753 T>G could influence the binding of miR-875-5p and CAPZA1 3′UTR(T), which indicated that miR-875-5p has a tumor-promoting function by down-regulation of CAPZA1 in ESCC. This evidence concerns the gene CAPZA1 and esophageal squamous cell carcinoma.