Although CAPZA1 has been reported to have ectopic expression in neuroblastoma, malignant melanoma, and gastric, liver, gastric, and breast cancers (Deng, Li & Zheng, 2017; Lee et al., 2013; Lo et al., 2007; Yu et al., 2011), little is known regarding the specific functions of CAPZA1 in ESCC. The gene discussed is CAPZA1; the disease is melanoma.