Then, we investigated the downstream gene of miR-875-5p using public databases, and unexpectedly found that miR-875-5p targeted CAPZA1 3′UTR containing the SNP, rs373245753 (Lewis et al., 2003; John et al., 2015), which was identified in our previous study involving WGS and WES in ESCC (Song et al., 2014). Here, CAPZA1 is linked to esophageal squamous cell carcinoma.