These included established atherosclerotic cardiovascular disease, diabetes with one additional risk factor (such as cigarette smoking, hypertension, high CRP, or microalbuminuria) and had high-risk primary prevention (age > 50 years for men, >60 years for women, family history of premature CAD, cigarette smoking, CRP > 2.0 mg/l, deranged renal function, or coronary calcium score > 300 Agatston units. The gene discussed is CRP; the disease is Hypertension.