Then, 20 main targets highly correlated with NAFLD were screened out from the online database, including TNF, AKT, caspase-3, etc. Furthermore, GO and KEGG analyses showed that SZ was capable of regulating multiple biological processes and pathways enriched in NAFLD, TNF-α, apoptosis, T2DM, lifespan regulation, adipokines, insulin resistance pathway, etc. In another network pharmacology analysis of SZ in the treatment of asthma, 22 effective chemicals were extracted, which were similar to our study. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.