Furthermore, phosphorylation of AKT, ERK, and NF-κB was closely related to the tumor metastasis and angiogenesis [41], which was demonstrated in our study that IL-8 may stimulate the upregulation of p-AKT, p-ERK, and p-NF-κB, which were inhibited by both JR. Here, NFKB1 is linked to neoplasm.