TNF and non-Hodgkin lymphoma: The T-helper cell 1/T-helper cell 2 (Th1/Th2), that is responsible for the secretion of IL-2, IFN-γ, TNF-α, and the secretion of IL-4, IL-5, IL-10, and IL-13, respectively, is decreased initially, and increased after the cessation of G-CSF, following APBSCT, leading to an increase in lymphocytes in NHL patients [29].