Meanwhile, the tissue distress factor, high-mobility group box-1 (HMGB1) [79], Ccl27-Ccr10 chemotactic axis [80], and SDF-1α/CXCR4 signaling axis [72] have been shown to promote the recruitment of endogenous MSCs to skin lesions, thus attenuating the pathology of epidermolysis bullosa. This evidence concerns the gene HMGB1 and epidermolysis bullosa.