BDNF and Alzheimer disease: It was observed that acupuncture could upregulate the expression of Trk-B receptors and could decrease the expression level of p75NTR in AD and VaD murine models, influence the modulation and processing of the BDNF protein from pro-BDNF to mature BDNF [33, 96, 97], and eventually enhance the mRNA expression levels of mature BDNF [35, 45, 54, 81].