Consistent with our results, the levels of NLRP3 inflammasome are substantially elevated both in brains from AD patients [10] and several rodent AD models [10, 12, 13, 48], since previous studies have shown that NLRP3 inflammasome activation induces the cleavages of cytokine precursors to generate active IL-1β and IL-18 [9]. Here, NLRP3 is linked to Alzheimer disease.