IGFBP2 and glioblastoma: We totally identified 2050 upregulated and 385 downregulated PCGs (Figure 1C and Supplementary Table 2), among which TNC (Nie et al., 2015; Xia et al., 2016), IGFBP2 (Hsieh et al., 2010; Patil et al., 2015), and EGFR (Giannini et al., 2005; Beck et al., 2011) ranked in the top 10 DEGs and were all reported to be associated with gliomagenesis and GBM invasion.