Previous studies have revealed that S100A10 could form a heterotetramer with ANXA2 to promote tumor cell invasion (Chen C.Y. et al., 2018) and S100A11 could also interact with ANXA1 which is a Ca 2+-regulated phospholipid-binding protein (Boudhraa et al., 2016) to form Ca 2+-dependent heterotetramers. The gene discussed is ANXA2; the disease is neoplasm.