To uncover whether alteration of the three genes is TBI specific or reflect a broader response to brain injury, we analyzed the expression of Igfbp7/IGFBP7, Fxyd5/FXYD5, and Itm2a/ITM2A in EC in response to stoke, seizure, and EAE in Munji’s study (Munji et al., 2019), as well as in the human glioblastoma vasculature in our previous study (Dieterich et al., 2012). Here, IGFBP7 is linked to glioblastoma.