U2AF homology motif kinase 1 facilitates the nuclear enrichment of MYB proto-oncogene like 2 by affecting the expression of CCNB2 to regulate cell cycle and proliferation (Wei et al., 2019), and reduced transmembrane protein 9 can contribute to decreased CCNB2 levels and then promote cell cycle arrest in HCC cells (Zhang et al., 2016). Here, TMEM9 is linked to hepatocellular carcinoma.