PPARA and Disorder of lipid metabolism: We found the differences in a number of genes annotated to differentially acetylated peaks and revealed their associated signaling pathways, supporting the notion that dysregulation of H3K27 acetylation and the PPAR signaling pathway are involved in the excessive accumulation of fat in liver tissue and the onset of lipid metabolic disorders (Chinetti et al., 2000; Beacon et al., 2020).