AKT1 and familial pancreatic carcinoma: IGF2BP2 overexpression was observed in pancreatic cancer, colorectal cancer, and SCCHN, which promoted cancer cell proliferation by activating the PI3K/Akt signaling pathway (Ye et al., 2016; Wang et al., 2019; Xu et al., 2019; Deng et al., 2020).