When compared to the healthy cohort, five parameters containing CD3+CD4+ T cell percentage (p=0.002), and CD3+CD4+CXCR5-CXCR3-CCR4+ Th2 cell percentage (p=0.002), CD3+CD4+CXCR5+CXCR3-CCR4+ Tfh2 cell percentage (p=0.000) and CD3+CD8+CXCR5-CXCR3-CCR4+ Tc2 (p=0.038) were overexpressed and CD3+CD4+CXCR5+CXCR3+CCR4- Tfh1 (P=0.038) cells and CD3+CD8+CXCR5-CXCR3-CCR4-CCR6+ Tc17 (P=0.018) were underexpressed significantly in gout populations. This evidence concerns the gene CD4 and gout.