IFI16 and viral infectious disease: Moreover, hnRNPA2B1 can disassociate with fat mass and obesity-associated protein (FTO) after virus infection, leading to the promotion of N6-methyladenosine (m6A) modification, nucleocytoplasmic trafficking, and translation of cGAS, STING, and IFI16 mRNAs to amplify the activation of IFN-Is in antiviral innate immune response (20).