Additionally, cytosolic DNA binds to the receptor absent in melanoma 2 (AIM2), leading to the recruitment of the apoptosis-associated speck-like protein containing CARD (ASC) and pro-caspase-1 to assemble a multi-protein complex termed inflammasome, which constitutes a group of PRRs and plays essential roles in response to viral infection (8). This evidence concerns the gene PYCARD and viral infectious disease.