FCGR2B and Autoimmunity: Given that decreased CD32b expression on B cells is a feature of several autoimmune conditions (25–27) and plays an important role in maintaining peripheral B cell tolerance (28), we hypothesised that CD32b expression on B cell subsets from people with recently diagnosed MS or clinically isolated syndrome (CIS; pre-MS) would be lower than levels on B cells from healthy controls, and also examined the effect of CD32b engagement on cytokine expression following antigen-independent stimulation in the presence of IgG-IC.