Dr. Deborah Merke (NIH, Bethesda MD) found that 7% of patients with 21OHD had symptomatic TNX haploinsufficiency (70, 71), and a recent study reported 14% (72); this association is now regarded as a sub-type of 21OHD termed CAH-X (73). This evidence concerns the gene TNXB and congenital adrenal hyperplasia.