TBK1 and infection: Mutant cells for TLR3 +/- (2018), TRIF, TLR3 +/- (1323), Nemo, TBK1 and TLR3-/- showed a higher susceptibility to infection than the immortalized fibroblasts from healthy donors (C65 & C72) with respectively 25%, 35%, 50%, 60%, 60% and 90% of infected cells, compared to 10-15% for healthy controls C65 and C72 cells, at 0.5 MOI (Figure 1B).