Safe and efficacious neuromodulatory approaches offer the prospect of treatment on comorbid BD with migraine in the future, as clinical researches on TMS or VNS to treat comorbid BD and migraine are expected to show effective therapeutic and cognitive improvement, as well as long-term follow-up studies about the changes in inflammatory factors, leptin and adipokines before and after treatment. The gene discussed is LEP; the disease is migraine disorder.