The immunocytokine, anti-CD20-IFN-α clearly showed that type I IFNs could have direct cytotoxic effects in lymphoma, which is very sensitive to type I IFN receptor-mediated tumor killing (Rossi et al., 2009; Xuan et al., 2010; Trinh et al., 2013). This evidence concerns the gene IFNA1 and lymphoma.